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Editor's Correspondence
January 14, 2008

Effects of Garlic on Cholesterol: Not Down But Not Out Either

Arch Intern Med. 2008;168(1):111-112. doi:10.1001/archinternmed.2007.24

Gardner and colleagues1 are to be congratulated on their well-conducted study of the effects of garlic materials on low-density lipoprotein cholesterol (LDL-C). But despite the trial's null outcome, the garlic-cholesterol hypothesis should not yet be consigned to history. This is because, although well designed in terms of blinding, compliance, randomization, and power calculations, different results might have been produced by doses differing in type, bioavailability, level, and duration and by different outcome measurement and analysis.

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