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Editor's Correspondence
January 14, 2008

Effects of Garlic on Cholesterol: Not Down But Not Out Either—Reply

Arch Intern Med. 2008;168(1):112-113. doi:10.1001/archinternmed.2007.14

In reply

We recently reported the effects of garlic products on blood lipids among adults with moderately elevated LDL-C in a placebo-controlled randomized controlled trial.1 These 3 products—dried powdered garlic, aged garlic extract, and mashed raw garlic—were extensively chemically characterized before and throughout the intervention.2 Monthly blood samples were collected for 6 months for 192 randomized participants (87%-90% retention per treatment group). None of these garlic products had statistically or clinically significant effects on LDL-C or plasma lipid concentrations. We believe that this trial successfully addressed the limitations of many previous trials examining possible effects of garlic on blood lipid levels.3,4

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