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Editor's Correspondence
March 10, 2008

Is Aspirin Resistance Due to Noncompliance?—Reply

Arch Intern Med. 2008;168(5):550. doi:10.1001/archinte.168.5.550-a

In reply

Heterogeneity is often an important problem in meta-analyses and complicates drawing overall conclusions. As correctly pointed out by Fontana and Reny in their letter and also acknowledged in the “Comment” section of our systematic review on the clinical consequences of laboratory aspirin resistance,1 the studies in our review are heterogeneous in many ways, regarding, for example, study population and definition of aspirin resistance. This is probably reflected by the statistical heterogeneity present in the pooled analysis, though, parenthetically, it would not be ruled out by statistical homogeneity.