We thank Katsiki and Manes for their interest in our study,1 which addresses the role of antioxidant vitamins, alone and in combination, in the prevention of cardiovascular events. Although our trial included only women, several antioxidant trials have been conducted in men or women separately, with similar results.2
Cook NR, Albert CM, Manson JE, WACS Investigator Group. Clinical Trials of Antioxidant Supplementation in the Prevention of Cardiovascular Events—Reply. Arch Intern Med. 2008;168(7):773–774. doi:10.1001/archinte.168.7.773-b
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