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Editor's Correspondence
July 14, 2008

Mortality in Humans With Pneumonia and Sepsis Is Related to an Uncompensated Anti-inflammatory Response to Infection

Arch Intern Med. 2008;168(13):1468-1469. doi:10.1001/archinte.168.13.1468-b

In the interesting article by Kellum et al1 on the systemic cytokine response to pneumonia in a cohort study of 1886 subjects hospitalized for community-acquired pneumonia (CAP), the authors report that the highest risk of death was with combined high levels of the proinflammatory cytokine interleukin (IL)-6 and the anti-inflammatory cytokine IL-10. They conclude that mortality is highest when both anti-inflammatory and proinflammatory cytokine levels are high.