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Editor's Correspondence
July 14, 2008

Dehydroepiandrosterone Sulfate Has Not Been Substantiated as an Anabolic Hormone—Reply

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Intern Med. 2008;168(13):1470. doi:10.1001/archinte.168.13.1470-b

In reply

We thank Dhatariya for his comments on our study.1 Dhatariya mentions that there is no reason to include DHEA-S in the group of anabolic hormones. Although some studies in women partially support Dhatariya's arguments,2 there is enough evidence in the literature that DHEA-S exerts an anabolic effect on several tissues, which may be direct or mediated by the conversion to testosterone or by the stimulation of insulinlike growth factor 1 secretion.3 A number of observational studies show a significant positive association between serum DHEA-S levels and muscle mass and strength and a negative association with fat mass in both men and women.4,5 There is also evidence that DHEA-S is positively associated with bone mineral density (BMD) in the older population.6