Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008
We thank Dhatariya for his comments on our study.1 Dhatariya mentions that there is no reason to include DHEA-S in the group of anabolic hormones. Although some studies in women partially support Dhatariya's arguments,2 there is enough evidence in the literature that DHEA-S exerts an anabolic effect on several tissues, which may be direct or mediated by the conversion to testosterone or by the stimulation of insulinlike growth factor 1 secretion.3 A number of observational studies show a significant positive association between serum DHEA-S levels and muscle mass and strength and a negative association with fat mass in both men and women.4,5 There is also evidence that DHEA-S is positively associated with bone mineral density (BMD) in the older population.6
Maggio M, Ceda GP, Basaria S, Valenti G, Ferrucci L. Dehydroepiandrosterone Sulfate Has Not Been Substantiated as an Anabolic Hormone—Reply. Arch Intern Med. 2008;168(13):1470. doi:10.1001/archinte.168.13.1470-b
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