It has been almost a decade since the publication of To Err Is Human: Building a Safer Health System1 in 2000 and Crossing the Quality Chasm: A New Health System for the 21st Century2 in 2001. In the interim, it has become routine to decry the high cost and numerous deficiencies in the quality of health care delivery in the United States, so routine that the Archives of Internal Medicine editorial office has given lower priority to manuscripts that simply describe quality deficiencies. We have placed greater priority on manuscripts investigating the root causes of quality deficiencies and manuscripts reporting results of efforts to improve health care quality. Increasing numbers of investigators are turning their attention to interventions that may improve health care quality, and 3 reports in this issue of the Archives exemplify this body of work by demonstrating different approaches to improving the efficiency and effectiveness of health care.