THE DIRECT RELATION between elevations in low-density lipoprotein cholesterol (LDL-C) and increased risk of coronary heart disease (CHD) is widely accepted in the clinical setting. Furthermore, a number of controlled clinical trials have confirmed that pharmacologic management of LDL-C can markedly reduce the incidence of acute coronary events in selected patients both with and without clinically known CHD.1-4
Gotto AM. Prognostic and Therapeutic Significance of Low Levels of High-Density Lipoprotein Cholesterol: Current Perspectives. Arch Intern Med. 1999;159(10):1038–1040. doi:10.1001/archinte.159.10.1038
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