THE ROLE of low-density lipoprotein (LDL) cholesterol in the pathogenesis of coronary artery disease and the importance of statin therapy in lowering LDL cholesterol in individuals with symptomatic1,2 and asymptomatic3,4 coronary artery disease is now well established. The relatively recent but already classic trials in patients with symptomatic coronary artery disease (the Scandinavian Simvastatin Survival Study1 and the Coronary Atherosclerosis and Recurrent Events trial2) and in asymptomatic individuals with increased risk because of elevated LDL cholesterol levels (the West of Scotland Coronary Prevention Study3) or because of low high-density lipoprotein cholesterol levels (the Air Force/Texas Coronary Artery Prevention Studies4 [AFCAPS/TexCAPS]) have shown that lowering LDL cholesterol level is the key to decreasing total mortality1,2 and preventing the complications of coronary artery disease.1-4
Ewy GA. Antioxidant Therapy for Coronary Artery Disease: Don't Paint the Walls Without Treating the Termites! Arch Intern Med. 1999;159(12):1279–1280. doi:10.1001/archinte.159.12.1279
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