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Invited Commentary
December 14, 2009

Antidepressant Use, Depression, and Poor Cardiovascular Outcomes: The Chicken or the Egg?Comment on “Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study”

Arch Intern Med. 2009;169(22):2140-2141. doi:10.1001/archinternmed.2009.437

Depression is a common comorbidity in patients with chronic heart failure, with reported incidence as high as approximately 48% in this patient population.1-4 Studies have shown that depression in patients with heart failure is strongly associated with worse outcomes and is an independent predictor of increased mortality and hospitalization.5-9 As a result, the use of antidepressants in this population has become more prevalent.

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