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Editor's Correspondence
April 26, 2010

Progression of Coronary Artery Calcification: Not Down-and-Out

Author Affiliations

Author Affiliations: Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland.

Arch Intern Med. 2010;170(8):735-736. doi:10.1001/archinternmed.2010.60

In the December 14, 2009, issue, McCullough et al1 presented a systematic review of randomized trials that used coronary artery calcification (CAC) progression as the primary end point. Despite the noninclusion of 2 eligible randomized placebo-controlled trials,2,3 we agree with their assertion that CAC progression has not been consistently reduced in any therapeutic randomized trial to date.

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