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Editor's Correspondence
May 24, 2010

HIV Infection and Esophageal Cancer—Reply

Author Affiliations

Author Affiliations: Department of Pathology, Tufts University School of Medicine, Baystate Medical Center, Springfield, Massachusetts (Dr Pantanowitz); Departments of Oncology and HIV Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital Foundation Trust, London, England (Dr Bower); Melanoma and Sarcoma Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York (Dr Krown); and Department of Medical Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London (Dr Stebbing).

Arch Intern Med. 2010;170(10):916-917. doi:10.1001/archinternmed.2010.114

In reply

We thank Dr Rastegar for sharing this interesting case. Some cases of esophageal cancer in HIV-infected individuals may well be linked to HPV infection. We observed 1 HIV-infected individual who had an HPV-related condyloma of his esophagus (Figure), who was not included in our published series because we only included cases of invasive esophageal carcinoma. Others have reported similar individuals with HPV-related esophagitis.1 Recent published data support an association between high-risk HPV and esophageal carcinomas,2,3 although causation is not established and is controversial.

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