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Editor's Correspondence
February 14, 2011

Vitamin D Efficacy and Safety

Author Affiliations

Author Affiliations: Osteoporosis Research Center, Creighton University, Omaha, Nebraska (Dr Heaney); Bone & Mineral Laboratory, Mount Sinai Medical Hospital, Toronto, Ontario, Canada (Dr Vieth); and Department of Pediatrics, Medical University of South Carolina, Charleston (Dr Hollis).

Arch Intern Med. 2011;171(3):266. doi:10.1001/archinternmed.2010.528

In the July 12, 2010, issue of the Archives,1 Grey and Bolland1(p1099) opine “it seems intuitively unlikely that a single hormone could play a substantial role in . . . the diverse range of diseases” linked to vitamin D. Forgetting for a moment the multiform effects of hormones such as cortisol and thyroxine, we note that vitamin D (as calcitriol) is not just a hormone but predominantly an autocrine agent.

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