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Clinical Observation
April 26, 1999

Diabetic Gustatory Sweating Successfully Treated With Topical Glycopyrrolate: Report of a Case and Review of the Literature

Author Affiliations

From the Department of Medicine, Kaiser Permanente Medical Center, Mountain View, Calif (Dr Urman), and the Department of Internal Medicine, Palo Alto Medical Foundation, Palo Alto, Calif (Dr Bobrove). Drs Urman and Bobrove are clinical professors of medicine, voluntary clinical faculty, at Stanford University Medical Center, Stanford, Calif.

Arch Intern Med. 1999;159(8):877-878. doi:10.1001/archinte.159.8.877

Background  Gustatory sweating is a more common manifestation of diabetes mellitus than is appreciated. It is a distressing problem that has been difficult to treat safely.

Methods  Daily topical application of glycopyrrolate roll-on lotion was offered as an alternative to oral anticholinergic agents to an 87-year-old woman with long-standing type 2 diabetes mellitus who complained of profuse sweating after eating.

Results  Gustatory sweating was relieved by application of glycopyrrolate and reappeared when the glycopyrrolate was briefly withdrawn to confirm its therapeutic effect.

Conclusion  For moderate to severe symptoms of diabetic gustatory sweating, topical application of glycopyrrolate is safe, effective, well tolerated, and convenient.