Additional Information: Drs Leontiadis and Howden have collaborated on systematic reviews and meta-analyses on the role of PPIs in ulcer bleeding for the Cochrane Collaboration.
In their recent meta-analysis, Wang and colleagues concluded that high-dose intravenous proton pump inhibitor (PPI) regimens were not superior to non–high-dose regimens for patients with recent ulcer bleeding.1 However, we consider these conclusions to be premature, possibly flawed, and potentially misleading.