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Editor's Correspondence
October 11, 2010

High-Dose vs Non–High-Dose PPIs After Endoscopic Treatment in Patients With Bleeding Peptic Ulcer: Current Evidence Is Insufficient to Claim Equivalence

Author Affiliations

Author Affiliations: Servicio de Aparato Digestivo, Hospital de Sabadell & Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas, Instituto de Salud Carlos III, Sabadell, Barcelona, Spain (Dr Calvet); Division of Gastroenterology, The McGill University Health Center, Montreal, Quebec, Canada (Dr Barkun); Faculty of Medicine, Institut National de la Santé et de la recherche Medicale, Dijon, France (Dr Bardou); Department of Medicine and Therapeutics, The Chinese University of Hong Kong (Dr Sung); and Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands (Dr Kuipers).

Arch Intern Med. 2010;170(18):1698-1699. doi:10.1001/archinternmed.2010.359

We read with interest the meta-analysis by Wang et al.1 The authors conclude that low-dose PPIs are as effective as high-dose PPI infusion to prevent recurrent peptic ulcer bleeding. In our opinion, there are strong methodological concerns about this study that could make its results and conclusions invalid. These concerns pertain both to the studies included in the analysis and to the methods used.

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