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Editor's Correspondence
Health Care Reform
March 14, 2011

Considering Selection Bias When Developing a Search Strategy

Author Affiliations

Author Affiliations: Department of Pharmacoepidemiology, Kyoto University Graduate School of Medicine and Public Health (Drs Y. M. Nakao and Kawakami), EBM Research Center (Drs Y. M. Nakao, Ueshima, Tanaka, Yasuno, Fujimoto, and K. Nakao) and Department of Medicine and Clinical Science (Dr K. Nakao), Kyoto University Graduate School of Medicine, and Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital (Dr Teramukai), Kyoto, Japan.

Arch Intern Med. 2011;171(5):471-472. doi:10.1001/archinternmed.2011.45

We read with great interest the article by Sciarretta et al1 on antihypertensive treatment and development of heart failure in hypertension. They performed the largest network meta-analysis in essential hypertension, to our knowledge, and showed that the use of diuretics and renin-angiotensin system inhibitors are the most effective first-line antihypertensive drug for preventing heart failure. In this meta-analysis, however, the search strategy and study selection are somewhat unclear.