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Editor's Correspondence
June 13, 2011

Lack of Cardiovascular Disease Among Old Order Amish With Familial Defective Apolipoprotein B

Author Affiliations

Author Affiliations: Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas.

Arch Intern Med. 2011;171(11):1039-1040. doi:10.1001/archinternmed.2011.238

We read with great interest the article by Shen et al1 reporting the prevalence of familial defective apolipoprotein B-100 due to R3500Q mutation in apolipoprotein B (APOB) in the Old Order Amish population. The authors concluded that this mutation was a major determinant of low-density lipoprotein cholesterol (LDL-C) levels and coronary artery calcification in the Amish.1

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