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Editor's Correspondence
June 13, 2011

Inverse Association Between Duration of Use of Acid-Suppressive Medications and Fracture Risk

Author Affiliations

Author Affiliation: Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands.

Arch Intern Med. 2011;171(11):1044. doi:10.1001/archinternmed.2011.226

The article by Abrahamsen et al,1 suggests that our article on proton pump inhibitor (PPI) use and fracture risk,2 has “suggested a causal relationship.”

This is not a correct interpretation of our findings: although we found a small overall association between PPI use and fracture, we emphasized that “there was inverse association between duration of use of acid-suppressive medications and fracture risk, which does not support adverse effects on the bone.”2(p1997)

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