Drs Angelo and Nardino are concerned about possible imbalances in the baseline characteristics of the patients in our study.1 Although we agree that abnormal liver function test results and variations in nutritional status and food and medication intake can all affect the anticoagulant response to warfarin sodium,2 there is no reason to suspect that these factors influenced the results of our investigation. We reached this conclusion for 2 reasons. The first is the fact that the patients were randomly allocated to the 2 treatment groups. This should minimize any systematic differences between the 2 groups. The second is the fact that the results of this study are similar to those we achieved in our previous article.3
Crowther MA. Comparing 5-mg and 10-mg Warfarin Loading Doses: Are the Groups Similar?. Arch Intern Med. 1999;159(14):1625. doi:
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