About 40% of patients infected with human immunodeficiency virus (HIV) are coinfected with hepatitis C virus (HCV), mainly because both viruses share the same routes of transmission. It has been demonstrated by several studies that HIV infection causes a more rapid progression of chronic hepatitis C to cirrhosis and liver failure.1,2 In agreement with that, increased degrees of hepatitis C viremia have been observed in coinfected patients.1,3 Among the mechanisms potentially implicated, interaction between the viruses and the immunosuppressive state induced by HIV infection have been suggested.3,4
Negredo E, Domingo P, Sambeat MA, Rabella N, Vázquez G. Influence of Coinfection With Hepatitis Viruses on Human Immunodeficiency Plasma Viral Load. Arch Intern Med. 1999;159(19):2367–2368. doi:
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