The article by Cantalamessa and colleagues1 points out that thyroid nodules occur with a high frequency in patients with Graves disease as determined by ultrasonography and pathological examination findings. Nevertheless, the authors discovered only 1 case of carcinoma among 315 consecutive patients (0.3%), including 106 with nodules. Surprisingly, this is a rather low frequency compared with previous studies and the findings from a recent series.2 We assume that this low frequency is the result of the fact that only 20 patients underwent surgery.
Čáp J, Ryška A. Thyroid Nodules and Carcinoma in Graves Disease. Arch Intern Med. 2000;160(10):1537–1538. doi:
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