It was intriguing going through the clinical observations of Kahn1 concerning patients with hypernatremia in association with edema. He described 7 hospitalized patients with hypoalbuminemia and azotemia presenting with increased serum sodium levels and marked edema.1 In this context, hypernatremia indicates sodium excess in the presence of fluid excess. Furthermore, urine output was increased, implying defective water conservation induced by a lower than expected level of antidiuretic hormone (ADH) activity caused 7y hypernatremia.1
Milionis HJ, Liamis G, Elisaf MS. Hypernatremia in Hospitalized Patients: A Sequel of Inadvertent Fluid Administration. Arch Intern Med. 2000;160(10):1537–1538. doi:
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