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Editor's Correspondence
June 12, 2000

Pneumococcal Vaccination of the Elderly: Do We Need Another Trial?—Reply

Arch Intern Med. 2000;160(11):1699. doi:

In reply

Hak and colleagues raise important questions regarding the incremental benefits of pneumococcal vaccination over influenza vaccination alone among community-dwelling elderly persons.

In our 2-year cohort study of 1898 persons with chronic lung disease, we found that pneumococcal vaccination was associated with significant reductions in hospitalizations for pneumonia and deaths from all causes.1 In our multivariate analyses, we controlled for influenza vaccination status for each of the two influenza seasons included in the 2-year follow-up period. Thus, our findings present the statistically significant independent contribution of pneumococcal vaccination status. There was no evidence of interaction between the two vaccinations, suggesting that their benefits were additive.

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