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Editor's Correspondence
July 10, 2000

The Need for Improving Information Systems on Drug Interactions in Japan—Reply

Arch Intern Med. 2000;160(13):2061-2067. doi:

In reply

We appreciate the insight provided by Harada and Fujimura and share their concerns regarding the reliability of information surrounding drug interactions.1 Within the last decade, our understanding of the P-glycoprotein and cytochrome P450 systems has dramatically improved. Unfortunately, a disturbing number of life-threatening drug interactions also have been discovered among the medications approved by the Food and Drug Administration (FDA) during this same period.

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