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Editor's Correspondence
July 10, 2000

Is There Enough Evidence That Low-Molecular-Weight Heparin Is Superior to Unfractionated Heparin in Pulmonary Embolism?

Arch Intern Med. 2000;160(13):2061-2067. doi:

In this well-designed study, Hull et al1 showed 7 new episodes (6.8%) of venous thromboembolism in 103 patients who received intravenous heparin. None of the patients in the low-molecular-weight heparin (LMWH) group had a recurrence. Out of 7 patients, 1 patient had a subtherapeutic activated partial thromboplastin time while receiving heparin, and 2 patients had subtherapeutic prothrombin times before or at the time of a recurrent thromboembolic event. This may be a potential confounder.

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