Tumor spread occurs when neoplastic cells cross blood vessels of a target tissue. This event takes place through the activation of several enzyme systems released by neoplastic cells that degrade the complex molecular architecture of vascular basal membranes.1 In the blood vessels of patients with long-standing diabetes mellitus (DM), the presence of irreversible advanced glycosylated end products may render the structure of basal membranes less digestible by tumor enzymes.2 Preliminary evidence suggests that vessel changes associated with long-standing DM (ie, diabetic microangiopathy) impede neoplastic cell spread and metastasis.3
De Giorgio R, Barbara G, Cecconi A, Corinaldesi R, Mancini AM. Diabetes Is Associated With Longer Survival Rates in Patients With Malignant Tumors. Arch Intern Med. 2000;160(14):2217. doi:
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