In a previous communication1 we demonstrated the following properties of pneumonic lung exudates:
Salt solution extracts of human lungs in the stage of gray hepatization in pneumococcus lobar pneumonia are more toxic for experimental animals than similar extracts of normal lung tissue. The method of extraction influences the toxicity of both extracts.
Lethal doses of extracts of both pneumonic and normal lung tissue injected intravenously usually produce anaphylactic-like symptoms.
Sterile extracts of pneumonic lung tissue of dogs removed forty-eight hours after intrabronchial insufflation of virulent pneumococci are more toxic than similar extracts of consolidated lung following intrabronchial insufflation of sterile aleuronat in suspension and both of these are somewhat more toxic than extracts of equal weights of normal dog lung.
The toxicity of extracts of normal and pneumonic lung is decreased by heating, drying and filtration through porcelain filters.
Extracts of human pneumonic lungs in gray hepatization are hemolytic for guinea-pig cells, whereas similar
WEISS C. BIOCHEMICAL STUDIES OF PNEUMONIC EXUDATES: WITH SPECIAL REFERENCE TO THE MECHANISM OF THE CRISIS IN PNEUMONIA STUDIES IN PNEUMONIA. X. Arch Intern Med (Chic). 1919;23(3):395–408. doi:10.1001/archinte.1919.00090200128010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: