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April 1919

THE BASAL METABOLISM IN ANEMIA WITH ESPECIAL REFERENCE TO THE EFFECT OF BLOOD TRANSFUSION ON THE METABOLISM IN PERNICIOUS ANEMIA

Arch Intern Med (Chic). 1919;23(4):441-454. doi:10.1001/archinte.1919.00090210035004
Abstract

HISTORICAL  In spite of critical reviews of the investigations on metabolism in anemia published by Strauss,1 in 1906, and Meyer and DuBois,2 in 1916, it will be profitable to discuss again the material which has been presented.

1. Animal Experimentation.  — Work on metabolism in anemic animals has concerned itself almost entirely with posthemorrhagic conditions. Thus Bauer,3 under the complex disturbances immediately following blood loss, found the metabolism slightly diminished; Delchef4 found it normal or slightly diminished; Finkler5 and Pembrey and Gürber6 found it normal; Fredericq7 found it transiently diminished and then elevated; Lukjanow8 and Hári9 found it elevated. Bauer3 reported a remarkably diminished metabolism a few days after bleeding. His work has been justly criticized by Pembrey and Gürber,6 who found no changes from the time of hemorrhage until recovery, and their findings are apparently verified by Hári,9 who has reported so slight an elevation during the period of

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