The observations of Christian1 on renal function in pernicious anemia, in which he found a disturbance in chlorid excretion, have suggested the study of the plasma and urinary chlorids in experimentally induced anemia in dogs. It was noted by Christian that urinary chlorid excretion in pernicious anemia, as measured by a two-hour renal test, approximated the characteristics of chronic nephritis. There was the same tendency to a fixation of urine chlorid percentage and impaired ability to concentrate the chlorids in the urine. These findings were not dependent on a concomitant nephritis or arteriosclerosis, and the disturbance lessened as the anemia improved. It was therefore pointed out by Christian that the presence of anemia as a factor would have to be considered in the interpretation of dietary renal tests on patients thought to have chronic nephritis. The determination of the plasma chlorid content was not taken up in his paper. To
STEINFIELD E. THE PLASMA CHLORIDS IN ANEMIA: AN EXPERIMENTAL STUDY. Arch Intern Med (Chic). 1919;23(4):511–514. doi:10.1001/archinte.1919.00090210105008
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