As an introduction to a study of liver injury due to chloroform anesthesia, it is necessary to understand clearly how uniform is the individual reaction to this drug under uniform conditions. We submit data in the following papers sufficient to convince a sceptic that the liver injury in a given dog will be uniform in extent provided the intake of food is accurately controlled and the dog is in good clinical condition. The evidence shows that a unit injury due to a unit chloroform anesthesia under fasting conditions will be repeated accurately again and again, provided the dog is given sufficient time to repair each injury to normal. This gives us much confidence in the interpretation of results and enables us to draw finer distinctions in type and extent of injury. In a review of the literature it will be noted that there is the greatest amount of variation in
DAVIS NC, WHIPPLE GH. THE INFLUENCE OF FASTING AND VARIOUS DIETS ON THE LIVER INJURY EFFECTED BY CHLOROFORM ANESTHESIA: PAPER I. Arch Intern Med (Chic). 1919;23(5):612–635. doi:10.1001/archinte.1919.00090220080006
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