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Article
June 1919

LIVER REGENERATION FOLLOWING CHLOROFORM INJURY AS INFLUENCED BY VARIOUS DIETS: MECHANISM OF PROTEIN SPARING ACTION OF FAT PAPER IV

Author Affiliations

SAN FRANCISCO

From the George Williams Hooper Foundation for Medical Research, University of California Medical School.

Arch Intern Med (Chic). 1919;23(6):711-722. doi:10.1001/archinte.1919.00090230057003
Abstract

This article cannot be looked on as complete in any sense, yet the data have considerable value in conjunction with the experiments given in the other papers of the series. It is evident that more experiments are needed to determine the exact influence of the cooked parenchymatous organs and organ extracts on liver cell repair. Incomplete proteins, for example, gelatin, should be tested to ascertain if possible what repair can take place on such diets. The lipoids and allied substances may have a part in this reaction and the influence of thyroid and other ductless glands or extractives of these glands should be worked out. Some of this work we hope to carry out in the near future.

From the experiments at hand it is clear that the liver will regenerate at maximum speed following a unit chloroform necrosis if the animal is fed a diet rich in carbohydrate, a

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