It has been well established that one of the characteristic features of one type of chronic nephritis is the retention of nitrogen. This has been demonstrated in a number of different ways, beginning with the observation of Bright that there was an increase of urea in the blood. Modern methods have elaborated on the original findings and in recent years metabolic studies of these cases have shown a positive balance between intake and output of nitrogen. I have reported studies of this kind, demonstrating that with certain cases the retention may be more than one gram of nitrogen a day, when the protein intake is equivalent to 10 gm. of nitrogen per day.
It occasionally happens, with cases of this kind, that there is no commensurate increase in the nonprotein nitrogen of the blood during a period of observation. This gives rise to the question: where is this retained nitrogen
FOSTER NB. THE INCREASE OF EXTRACT NITROGEN IN THE TISSUES, WITH CHRONIC NEPHRITIS. Arch Intern Med (Chic). 1919;24(2):242–246. doi:10.1001/archinte.1919.00090250115004
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