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INTRODUCTION AND METHODS
This electrocardiographic study was stimulated by the observation of the effect of epinephrin on "irritable heart" cases. In a number of these cases (about 60 per cent.), from twenty to fifty minutes after the injection was made very pronounced changes were induced. There was considerable rise in blood pressure and pulse rate, the patients became dyspneic, complained of precordial pain and dizziness, their hands became cold and tremulous, they became conscious of palpitation, etc.—in a word they seemed to be suffering from the sort of symptoms which had been the original cause for admission to the hospital. In normal trained soldiers this injection produced changes which were essentially negligible.On account of the effect of epinephrin on the circulation it seemed desirable to find out whether electrocardiographic tracings would show any changes during the occurrence of these symptoms. About eighteen cases of "irritable heart" were studied. The
CLOUGH HD. STUDIES ON EPINEPHRIN. IIIEFFECT OF EPINEPHRIN ON THE ELECTROCARDIOGRAMS OF PATIENTS WITH "IRRITABLE HEART". Arch Intern Med (Chic). 1919;24(3):284–294. doi:10.1001/archinte.1919.00090260039003
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