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Article
October 1919

THE PRODUCTION OF BRIGHT'S DISEASE BY FEEDING HIGH PROTEIN DIETS

Author Affiliations

ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan.

Arch Intern Med (Chic). 1919;24(4):359-377. doi:10.1001/archinte.1919.00090270003001
Abstract

For nearly a century the etiology of Bright's disease has been the subject of much medical thought and investigation. But in spite of this, the clinician is still unable to find a cause for the disease in the great majority of cases seen by him. The present investigation was undertaken with the hope of throwing some additional light on this difficult subject.

The chief business of the kidneys is to rid the organism of the end products of protein metabolism. This task is accomplished to a considerable extent by active secretion on the part of certain portions of the tubular epithelium. These cells will not only remove normal waste, but they will also remove from the blood stream substances which are foreign to it even though they may be severely injured by the poisons passing through them. Thus investigators1 have shown that when the kidney eliminates such substances as mercury,

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