In the foregoing paper1 it has been shown that acetylsalicylic acid, in 1 gm. doses, has but a slight effect on the heat balance of normal individuals. An average increase of 6.1 per cent. above the normal heat production was obtained in five cases, the maximum effect occurring during the fourth half hour after giving the drug by mouth. A very slight tendency to raise the body temperature was observed. In this paper will be reported the effects of acetylsalicylic acid given in the same amounts in fever cases. As will be seen from the data, during febrile and afebrile phases, as well as in the first stages of convalescence, similar phenomena have been manifested.
In determining the means by which a substance exerts its antipyretic action, it is necessary to know how the energy exchange is affected. Is the reduction in temperature due to an increase in heat elimination
BARBOUR HG. ANTIPYRETICS. III. ACETYLSALICYLIC ACID AND HEAT REGULATION IN FEVER CASES. Arch Intern Med (Chic). 1919;24(6):624–632. doi:10.1001/archinte.1919.00090290045005
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