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December 1919


Author Affiliations


Arch Intern Med (Chic). 1919;24(6):633-637. doi:10.1001/archinte.1919.00090290054006

Infection and intoxication are morbid processes which are undeniably the fundamental causes of abnormal mental functioning in a large group of cases. It has been sufficiently demonstrated that endogenous and exogenous toxic substances are apt to create products fit only for elimination, but not for cellular life; and that their contact with nerve elements exercises an obnoxious influence on the function of the latter.

The function of the brain may also be disturbed by bacterial poisons which engender microbic and cellular toxins. Although the precise action of the latter on the nerve cell is still somewhat obscure, nevertheless, its existence is a matter of daily observation. What is absolutely certain in this entire problem is the fact that the organism always endeavors to get rid of the exogenous, endogenous and bacterial poisons either through the kidneys, lungs, salivary and cutaneous glands by direct elimination, or by means of modification and

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