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December 1919


Author Affiliations


From the Medical Service of the Massachusetts General Hospital and the Medical Department of the Harvard Medical School, aided in part by a grant from the Proctor Fund, Harvard University.

Arch Intern Med (Chic). 1919;24(6):645-677. doi:10.1001/archinte.1919.00090290066008


  1. Introduction.

  2. Historical.

  3. Methods.

  4. Clinical AND Metabolism Data.

    1. Controls:

      • Normal (Table 1).

      • Miscellaneous Diseases (Table 1).

      • Nontoxic Goiters (Table 2).

      • Borderline Cases and Differential Diagnosis (Table 3).

    2. Exophthalmic Goiter:

      • Roentgen-Ray Series (Table 4).

      • Surgical Series (Table 5).

      • Miscellaneous Series (Table 6).

  5. Interpretation of Data.

    1. Effect of Rest.

    2. Effect of Roentgen Ray.

    3. Effect of Surgery.

    4. Roentgen-Ray and Surgery Compared.

    5. Relation of Metabolism to Other Factors.

    6. Metabolism as a Guide to Treatment.

  6. Conclusions.

INTRODUCTION  Four and one half years ago a study of the basal metabolism in exophthalmic goiter was started at the Massachusetts General Hospital. Preliminary reports on this work appeared in June, 1916,1 and in July, 1917.2 It was impossible for us at the latter date, because of the imminence of mobilization, to present more than the barest outline of our work, together with the conclusions drawn to that time.The original program of the research was to follow the metabolism and clinical condition of a series of cases of exophthalmic goiter over a period of several years, during which

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