It is generally agreed that the best method for diagnosing tuberculosis of the genito-urinary tract is by the inoculation of the urine of suspected cases into the peritoneal cavity of a guinea-pig. However, this test loses much of its practical value because of the time which must elapse before lesions are apparent in the guinea-pig after inoculation. This work has been undertaken with two purposes in view; first, to shorten the time of development of tuberculosis in guinea-pigs, so that inoculation tests will be of more practical value to the clinician; second, to determine the rôle of lymphocytes as a factor in the protection of guinea-pigs against tuberculous infection. The exposure of guinea-pigs to the roentgen ray was suggested by the favorable report of John H. Morton,1 in which it is stated that, whereas with ordinary technic a period of five weeks elapses before death, with the roentgen ray exposure
WEINBERG JA. THE INFLUENCE OF THE EXPOSURE TO THE ROENTGEN RAY ON THE PROGRESS OF TUBERCULOSIS. Arch Intern Med (Chic). 1920;25(5):565–573. doi:10.1001/archinte.1920.00090340116008
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