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Article
September 1920

NARCOTIC DRUG ADDICTION: I. THE FORMATION OF PROTECTIVE SUBSTANCES AGAINST MORPHIN

Author Affiliations

NEW YORK

From the Department of Pharmacology, University and Bellevue Hospital Medical College.

Arch Intern Med (Chic). 1920;26(3):279-292. doi:10.1001/archinte.1920.00100030023003
Abstract

The importance that has been attached to the problem of drug addiction in the past several years has prompted us to make a critical study of certain of its phases. While a considerable amount of experimental work has been done on the subject, it has not been wholly satisfactory in that the conclusions have been either conflicting or uncorroborated.

The first phase of the subject we undertook to study was the question as to whether the continuous taking of morphin causes the presence in the blood serum of any substance which has a protective effect against morphin.

LITERATURE  In 1897, Gioffredi,1 an Italian, published results of experimental work on alkaloidal immunization, in which he stated that while it was impossible to obtain immunity against the effects of cocain and atropin he was able to obtain a serum from a morphin tolerant dog which protected a second dog from almost twice

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