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Article
September 1920

A STUDY OF THE RENAL CONCENTRATION POWER FOR URIC ACID IN EARLY CHRONIC INTERSTITIAL NEPHRITIS: SECOND PAPER

Arch Intern Med (Chic). 1920;26(3):367-372. doi:10.1001/archinte.1920.00100030111011
Abstract

In a previous communication we presented a preliminary report of our work regarding the concentration power of the kidney for uric acid in early chronic interstitial nephritis. By the term interstitial nephritis was meant the renal anatomic lesion which is commonly associated with that condition. The cases presented as positive nephritis were only such as could readily be diagnosed by the conventional methods. It was shown that in such the renal concentration power for uric acid was markedly lowered, while in normal individuals no such lowering took place. A number of cases were also recorded in which a positive diagnosis of nephritis could not be made by the conventional methods. These cases, however, gave many suspicious symptoms of nephritis, and were, therefore, listed as questionable nephritis. They all showed lowering of the renal function for uric acid, and the thought was expressed by us that they were in reality positive

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