The chemical analyses of the blood and urine of five cases of tertiary syphilis form part of an investigation conducted in collaboration with Schamberg, Kolmer and Raiziss1 on the subject of the causes and mechanism of the severe reactions occasionally observed after the intravenous administration of alkaline solutions of arsphenamin. Since the clinical and pathological literature on arsphenamin reactions has frequently been reviewed, we will concern ourselves here with a small number of available papers that deal with strictly chemical investigations made by modern acceptable methods.
REVIEW OF THE LITERATURE
Very little literature is available concerning the effects of arsphenamin on metabolic processes. Marischler and Schneider,2 who were among the first to investigate this problem, unfortunately used the subcutaneous route of administration. Since the journal in which their paper is published is inaccessible, a brief summary of their work will be of interest. They investigated three cases of syphilis: one