In a previous paper1 attention has been directed to the fact that single determinations of gastric acidity by the Rehfuss method are not sufficient on which to base conclusions, because they do not take into account individual variation. Another important question which arises in evaluating results obtained by this method is whether the aliquot fractions aspirated are truly representative of the total gastric contents at the time of withdrawal. Recently, Gorham2 has shown that "the gastric chyme is not, in the majority of instances, a homogeneous mixture after a test meal, and that the acidity of different portions may vary widely." He found on the withdrawal in rapid succession of many samples that there was a marked variation in acidity of these samples in subjects having clinical evidence of gastric disease. Such variations were not so apparent in subjects without clinical evidence of gastric disease, although Wheelon3 has reported some
KOPELOFF N. VARIATIONS IN ALIQUOT FRACTIONS OF GASTRIC CONTENTS. Arch Intern Med (Chic). 1922;30(1):118–130. doi:10.1001/archinte.1922.00110070121010
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