Few estimations of blood volume have been made on obese persons, but those obtained have indicated a small blood volume in comparison with body weight. Haldane and Smith1 were the first to draw attention to this fact. Later, Keith, Rowntree and Geraghty2 showed that both the blood and plasma volumes were small in certain obese patients. Rasmussen and Rasmussen3 compared the blood volume in the woodchuck in midsummer, just before and during hibernation, and found that there was a relative reduction in blood volume when a maximum amount of fat was stored within the body. Our observations on a series of obese patients have confirmed this relationship between blood volume and excessive deposits of fatty tissue. In the present series, patients were also studied after they had lost a known amount of weight, chiefly to determine whether loss of weight brought about constant changes in blood and plasma volumes. Fourteen
BROWN GE, KEITH NM. BLOOD AND PLASMA VOLUME IN OBESITY. Arch Intern Med (Chic). 1924;33(2):217–223. doi:10.1001/archinte.1924.00110260063005
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