Of the enormous amount of work done concerning the concentration of ionized hydrogen in the body fluids, much is of more than abstract interest from the clinical point of view. The recognized fact that even in disease the true reaction of the blood varies within narrow limits has led to much study of the possible factors controlling this phenomenon. It is from work on this phase of the subject that observations primarily of interest to the physical chemist only have now become of interest and importance to the clinician.
In this communication, we are concerned only with the part that the kidneys play in the regulation of the body neutrality. The literature is enormous, and recently1 excellent reviews have appeared on the subject. Experimentally, an acidosis may be produced in man by proper changes in diet, such as restriction of carbohydrates or salts. Even under normal conditions of diet there
RABINOWITCH IM. THE ORIGIN OF URINARY AMMONIA: SECOND PAPER. Arch Intern Med (Chic). 1924;33(3):394–400. doi:10.1001/archinte.1924.00110270115010
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