Although one of the rarer pathologic lesions, the primary idiopathic splenomegaly of Gaucher has been the subject of considerable discussion. This has centered more particularly around the cytogenesis of the characteristic large round to oval or polygonal single or multinucleated cells, which comprise the bulk of the splenic tissue and account for the splenic enlargement. Since the original neoplastic conception of the nature of these cells was replaced by that of a hyperplasia, there have grown up two schools, one tracing their origin to the endothelial lining of the venous sinuses, the other to the reticular tissue of the pulp. The former view has been supported by Bovaird, Downes, Wilson, and others; the latter by Schlagenhaufer, Risel, De Jong and Van Heukelom, etc. A few have expressed the opinion that these cells may arise from either source.
Mandelbaum,1 in 1912, called attention to the fact that up until then no
WAUGH TR, MacINTOSH DS. THE HISTOGENESIS AND NATURE OF GAUCHER'S DISEASE. Arch Intern Med (Chic). 1924;33(5):599–610. doi:10.1001/archinte.1924.00110290066006