Hemoglobin estimations have for years been used for diagnostic and prognostic purposes, and have also played a part in the investigation of research problems in both medicine and physiology. Under various clinical and experimental conditions, wide variations in the hemoglobin content of the blood have been noted and numerous suggestions have been made to explain this. They are too numerous even to refer to here. If we take into consideration the phenomena recorded in this communication, it becomes obvious that inferences drawn from the hemoglobin variations are liable to be incorrect.
It is not generally recognized that, under ordinary conditions of life, variations of the hemoglobin content of the blood, even to the extent of 30 per cent., may and do frequently occur in the same person during the same day. That such variations do occur was brought to the attention of one of us (R.) some time ago by
RABINOWITCH IM, STREAN G. HEMOGLOBIN CONTENT OF THE RED BLOOD CELLS IN RELATION TO THEIR SURFACE AREA: PRELIMINARY REPORT. Arch Intern Med (Chic). 1924;34(1):124–128. doi:10.1001/archinte.1924.00120010135010
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