In the preceding paper of this series it was shown that a certain functional measurement varied in directproportion to the weight of normal renal tissue.1 If that is so, the removal of approximately 50 per cent. of the renal tissue of the body by means of a unilateral nephrectomy should lead to a 50 per cent. decrease in function. But since the conditions required for this particular functional measurement cannot be fulfilled immediately after an operation, and since unilateral nephrectomy is at once followed by a progressive increase in the size of certain parts of the secreting elements of the remaining kidney, it follows that the nephrectomy experiments which we report in this paper do not have that simplicity which was attained in the direct comparison of total renal weight and function. On the other hand, the specialized nature of the concomitant structural changes give them an added interest.
ADDIS T, MYERS BA, OLIVER J. THE REGULATION OF RENAL ACTIVITY: IX. THE EFFECT OF UNILATERAL NEPHRECTOMY ON THE FUNCTION AND STRUCTURE OF THE REMAINING KIDNEY. Arch Intern Med (Chic). 1924;34(2):243–257. doi:10.1001/archinte.1924.00120020109010
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