From the numerous data available, the deduction is that the chief function of the kidneys is to keep the composition of the blood constant. The kidneys must react to the various deviations from the normal composition of the blood by excreting water or substances dissolved in it. During the process of excretion work is done. All tests for renal efficiency are based on the ability of the kidneys to do their work. It is generally recognized that, since the complete mechanism of the secretion of urine is imperfectly understood, the total work done by the kidneys during this process cannot be accurately determined. Attempts have been made to estimate this work according to known physical principles. Of special note are the procedures of Dresser, Galeotti and Hill. The data thus obtained and some of the renal function tests now in use have been reviewed.1
In a recent communication2 a study
RABINOWITCH IM. A QUANTITATIVE INDEX OF KIDNEY FUNCTION: THERMODYNAMIC CONSIDERATIONS IN THE ESTIMATION OF RENAL EFFICIENCY. Arch Intern Med (Chic). 1924;34(3):365–373. doi:10.1001/archinte.1924.00120030100008
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