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Article
October 1924

STUDIES ON THE METABOLISM OF OBESITY: III. THE SPECIFIC DYNAMIC ACTION OF FOOD

Author Affiliations

WITH THE TECHNICAL ASSISTANCE OF ALICE D. SAUNDERS, B.A. CHICAGO

From the Medical Clinic, the Gusta Morris Rothschild Fund and the Otto Baer Fund for Clinical Research of the Michael Reese Hospital and the Nelson Morris Memorial Institute for Medical Research.

Arch Intern Med (Chic). 1924;34(4):573-583. doi:10.1001/archinte.1924.00120040159015
Abstract

The first line of experimentation followed by us in our studies on the metabolism of obesity was directed toward the possible discovery of variations in the specific dynamic action of foods in persons of widely different body build. In 1921 one of us1 reported our first experiments on the specific dynamic action of carbohydrate. No definite conclusions were drawn from this study. The work has subsequently been extended, until at the present time we are able to report the original series of experiments on carbohydrate utilization performed with the Benedict portable respiration apparatus, and a larger series done with the Tissot gasometer in which carbohydrate, protein and fat meals were studied.

When our work was first started, no very definite experimental data were available on variations in the specific dynamic action of foods. In the large series of cases studied by Benedict and Carpenter2 no attention was paid in the

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